Directed Catalytic Asymmetric Olefin Metathesis. Selectivity Control by Enoate and Ynoate Groups in Ru-Catalyzed Asymmetric Ring-Opening/Cross-Metathesis

摘要

Catalytic asymmetric olefin metathesis offers unique and efficient pathways for the synthesis of enantiomerically enriched molecules. High enantioselectivity has been achieved through steric and/or electronic tuning of catalysts, as well as by manipulation of the structure of olefins. Herein, we demonstrate that α, β-unsaturated carbonyls within a cross partner can significantly alter and enhance enantioselectivity in asymmetric ring-opening/cross-metathesis (AROM/CM) reaction.