Transition-State Analysis of the DNA Repair Enzyme MutY

Joe A. B. McCann; Paul J. Berti

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Transition-State Analysis of the DNA Repair Enzyme MutY

机译：DNA修复酶MutY的过渡态分析

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The transition state (TS) structure of MutY-catalyzed DNA hydrolysis was solved using multiple kinetic isotope effect (KIE) measurements. MutY is a base excision repair enzyme which cleaves adenine from 8-oxo-G:A mismatches in vivo, and also from G:A mism

机译：MutY催化的DNA水解的过渡态（TS）结构使用多重动力学同位素效应（KIE）测量得以解决。 MutY是一种碱基切除修复酶，可在体内从8-oxo-G：A错配以及从G：A mism切割腺嘌呤

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《Journal of the American Chemical Society》 |2008年第17期|5789-5797|共9页
作者
Joe A. B. McCann; Paul J. Berti;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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入库时间 2022-08-18 03:19:33

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1. Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain. [J] . Lee HeungMan, Wang Cheng, Hu Zhaoyong, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2002,第5期

机译：缺氧在体内可在大鼠脑中诱导线粒体DNA损伤并刺激DNA修复酶（大肠杆菌MutY DNA糖基化酶同源物（MYH））的表达。
2. Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria (vol 28, pg 1355, 2000) [J] . Ohtsubo T., Nishioka K., Imaiso Y., Nucleic Acids Research . 2015,第7期

机译：鉴定人类MutY同源物（hMYH）作为DNA中2-羟基腺嘌呤的修复酶并检测位于细胞核和线粒体中的多种形式的hMYH（vol 28，pg 1355，2000）
3. Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria [J] . H. Oda, H. Shimokawa, K. Nishioka, Nucleic acids research . 2015,第7期

机译：鉴定人类MutY同源物（hMYH）作为DNA中2-羟基腺嘌呤的修复酶并检测位于核和线粒体中的多种形式的hMYH
4. DNA repair enzyme analysis on EWOD fluidic microprocessor [C] . Dorothee Jary, Alexia Chollat-Namy, Yves Fouillet, Nano Science and Technology Institute(NSTI) Nanotechnology Conference and Trade Show(NSTI Nanotech 2006) vol.2 . 2006

机译：EWOD流体微处理器上的DNA修复酶分析
5. Mutations affecting the structure and catalytic activity of the DNA repair enzyme MutY. [D] . Chmiel, Nikolas Harmon. 2002

机译：影响DNA修复酶MutY的结构和催化活性的突变。
6. Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria [O] . T. Ohtsubo, K. Nishioka, Y. Imaiso, 2015

机译：鉴定人类MutY同源物（hMYH）作为DNA中2-羟基腺嘌呤的修复酶并检测位于核和线粒体中的多种形式的hMYH
7. Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain [O] . Heung-Man Lee, Cheng Wang, Zhaoyong Hu, 2002

机译：缺氧诱导线粒体DNA损伤，刺激DNA修复酶的表达，大肠杆菌蛋白DNA糖基糖基酶同源物（MYH），在大鼠脑中

Transition-State Analysis of the DNA Repair Enzyme MutY

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