The Sugar Conformation Governs (6-4) Photoproduct Formation at the Dinucleotide Level

摘要

Exposure of DNA to solar UV light induces structural modifications mostly in the form of covalent bond formation between two adjacent pyrimidines. As a result, two major types of DNA photoproducts (PPs), cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone photoproducts ((6-4) PPs), are formed (Figure 1). These DNA lesions are implicated in photoaging and skin cancer and induce differential biological effects.