Enzyme-Triggered Disassembly of Dendrimer-Based Amphiphilic Nanocontainers

摘要

Stimuli-responsive drug delivery systems have gained significant attention in recent years because their controlled release characteristics have resulted in enhanced efficacy at the site of action. Most of these systems respond to stimuli such as temperature, pH, light, magnetic fields, and ionic strength. An attractive class of responsive materials would involve molecular designs that respond to biological stimuli such as proteins, since overexpression of proteins, especially enzymes, has frequently been implicated in the diseased state of cells. Here, we disclose our findings on an enzyme-responsive dendrimer assembly.