Modular Design of Peptide Fibrillar Nano- to Microstructures

摘要

With a growing interest and demand for materials programmed at the nano-to-micrometer scales, biomolecular self-assembly is attracting considerable attention as an efficient tool for building new supramolecular architectures and composites.1 Self-assembled materials based on polypeptides have been developed extensively over the past decade. Within this area, the design of fibrous systems is particularly notable. Moreover, these are being made with various applications in mind, including templating inorganic nanostructures and as scaffolds for tissue engineering. Such materials have been built from three major protein-folding motifs: α-helices,β-pleated structures, and collagen triple helices. We have focused on α-helical assemblies.