Shape and Release Control of a Peptide Decorated Vesicle through pH Sensitive Orthogonal Supramolecular Interactions

摘要

One of the main challenges in supramolecular chemistry is the design of structurally well-defined architectures with dynamic and stimulus-responsive properties that emulate biological systems. Dynamic and adaptive supramolecular materials that self-assemble from multiple components will find a range of applications in materials and biomedicine. A number of fundamental studies in the field of supramolecular chemistry have demonstrated that more intricate and functional materials can be engineered from nonco-valent complexes by carefully combining several orthogonal interactions. The use of a scaffold for self-assembly is a particularly interesting option, since a scaffold can guide the organization of weakly interacting molecules into well-defined self-assembled architectures. In this paper, the pH sensitive β-sheet formation of an oligopeptide that self-assembles on the surface of a vesicle is used as a trigger for the release of contents through a reversible sphere-to-fiber transition of the vesicles.