Heavier Group 2 Metals and Intermolecular Hydroamination: A Computational and Synthetic Assessment

摘要

We have recently demonstrated that catalytic intramolecular hydroamination of aminoalkenes may be achieved through use of the d~o metals of group 2 (Scheme 1). In common with other metal-mediated transformations, the effect of ionic radius on reaction kinetics in organolanthanide(III) hydroamination catalysis is well-documented, and the reaction tends to proceed at lower rates with decreasing metal ionic radius. This effect has been ascribed to the greater degree of coordinative saturation at the electrophilic metal center, increasing the energy of the transition state of the rate-determining alkene insertion step.