Total Synthesis and Structure Elucidation of (+)-Phorbasin C

摘要

The phorbasins are a class of structurally novel diterpenes isolated from a southern Australian marine sponge (Phorbas sp.) that are structurally related to the terrestrial carvotacetone monoterpenes and carvone (Figure 1). Initial isolation of the phorbasins was prompted by an observed growth inhibitory activity of the crude extracts against Gram positive bacteria Staphylococcus aureus and Micrococcus luteus. More recently, studies have identified that members of this class possess a range of selective cytotoxic properties.