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首页> 外文期刊>Journal of the American Chemical Society >Light-Activated Regulation of Cofilin Dynamics Using a Photocaged Hydrogen Peroxide Generator
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Light-Activated Regulation of Cofilin Dynamics Using a Photocaged Hydrogen Peroxide Generator

机译：光活化过氧化氢发生器对光导蛋白的动力学调节。

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摘要

Hydrogen peroxide (H_2O_2) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H_2O_2 on demand upon photoacti-vation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H_2O_2 as well as remote control of cell behavior via H_2O_2-mediated pathways.
机译：过氧化氢（H_2O_2）可以根据其时空动态在生命系统内发挥多种信号和应激反应。在这里，我们报告一种新的小分子探针，用于在光活化后按需产生H_2O_2，并将其用于活细胞中cofilin-actin棒形成的光学调节。这种化学方法为剖析H_2O_2的生物学作用以及通过H_2O_2介导的途径远程控制细胞行为提供了许多潜在机会。

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  • 来源
    《Journal of the American Chemical Society》 |2010年第48期|p.17071-17073|共3页
  • 作者

    Evan W. Miller; Nicolas Taulet; Carl S. Onak; Elizabeth J. New; Julie K. Lanselle; Gillian S. Smelick; Christopher J. Chang;

  • 作者单位

    Department of Chemistry,University of California, Berkeley, California 94720, United States;

    Department of Immunology and Microbial Science and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, United States;

    Department of Chemistry,University of California, Berkeley, California 94720, United States;

    Department of Chemistry,University of California, Berkeley, California 94720, United States;

    Department of Chemistry,University of California, Berkeley, California 94720, United States;

    Department of Chemistry,University of California, Berkeley, California 94720, United States;

    Department of Chemistry,University of California, Berkeley, California 94720, United States ,Howard Hughes Medical Institute, University of California, Berkeley, California 94720, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 入库时间 2022-08-18 03:15:56

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