Non-Heme Iron Oxygenases Generate Natural Structural Diversity in Carbapenem Antibiotics

摘要

Carbapenem antibiotics are of clinical importance because of their high potency, broad spectrum of antimicrobial activity, and resistance to most β-lactamases. Thienamycin (1) (Figure 1), the most potent natural member of this family, co-occurs in Strepto-myces cattleya with four carbapenems that are distinguished by their C-2/C-6 substituents. There are more than 50 known carbapenam/ em metabolites, many of which are differentiated only by the oxidation state of their C-2/C-6 substituents.