Characterization of Dimeric Chiral Lithium Amide Structures Derived from AMsopropyl-O- triisopropylsilyl Valinol

摘要

The dimeric structure is characterized for a chiral amide base complex consisting of an (S)-N-isopropyl-O-triiso-propylsilyl valinol ligand and lithium. The complex is characterized by a variety of NMR techniques, including multinuclear one- and two-dimensional NMR experiments and diffusion-ordered NMR spectroscopy (DOSY) as well as diffusion coefficient-formula weight (D-fw) correlation analyses. Spartan calculations are presented which support the structural assignment. This structural characterization leads to an explanation of the behavior and the reactivity of these complexes in solution.