Engineering of Therapeutic Polypeptides through Chemical Synthesis: Early Lessons from Human Parathyroid Hormone and Analogues

Suwei Dong; Shiying Shang; Jianfeng Li; Zhongping Tan; Thomas Dean; Akira Maeda; Thomas J. Gardella; Samuel J. Danishefsky

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Engineering of Therapeutic Polypeptides through Chemical Synthesis: Early Lessons from Human Parathyroid Hormone and Analogues

机译：通过化学合成设计治疗性多肽：人类甲状旁腺激素及其类似物的早期教训

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Application of chemical synthesis to gain access to high purity hPTH as well as more stable analogues was accomplished through a menu of extended NCL followed by metal free dethiylation.

机译：通过扩展的NCL菜单，然后进行无金属脱硫烷基化，可以实现化学合成以获取高纯度hPTH以及更稳定的类似物的应用。

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来源
《Journal of the American Chemical Society》 |2012年第36期|p.15122-15129|共8页
作者
Suwei Dong; Shiying Shang; Jianfeng Li; Zhongping Tan; Thomas Dean; Akira Maeda; Thomas J. Gardella; Samuel J. Danishefsky;
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作者单位

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, United States;

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, United States;

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, United States;

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, United States;

Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, 51 Blossom Street, Boston, Massachusetts, United States;

Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, 51 Blossom Street, Boston, Massachusetts, United States;

Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, 51 Blossom Street, Boston, Massachusetts, United States;

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, United States,Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, New York 10027, United States;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Structure and activities of constrained analogues of human parathyroid hormone and parathyroid hormone-related peptide: implications for receptor-activating conformations of the hormones. [J] . Barbier JR, MacLean S, Morley P, Biochemistry . 2000,第47期

机译：人甲状旁腺激素和甲状旁腺激素相关肽的约束类似物的结构和活性：对激素受体激活构象的影响。
2. PROBING THE BIMOLECULAR INTERACTIONS OF PARATHYROID HORMONE WITH THE HUMAN PARATHYROID HORMONE PARATHYROID HORMONE-RELATED PROTEIN RECEPTOR .1. DESIGN, SYNTHESIS AND CHARACTERIZATION OF PHOTOREACTIVE BENZOPHENONE-CONTAINING ANALOGS OF PARATHYROID HOR [J] . Nakamoto C, Behar V, Chin KR, Biochemistry . 1995,第33期

机译：甲状旁腺激素与人甲状旁腺激素相关的蛋白受体的双分子相互作用的研究1。甲状旁腺激素的光反应性苯甲酮类似物的设计，合成与表征
3. Expression-level dependent activation of recombinant human parathyroid hormone/parathyroid hormone-related peptide receptor: Effect of human parathyroid hormone (1-34), (1-31), and (28-48) [J] . Tonn O., Braitmaier A., Schafer W., Journal of receptor and signal transduction research . 2000,第2a3期

机译：重组人甲状旁腺激素/甲状旁腺激素相关肽受体的表达水平依赖性激活：人甲状旁腺激素（1-34），（1-31）和（28-48）的作用
4. Highly potent analogs of human parathyroid hormone and human parathyroid hormone-related protein [C] . Jesse Z.Dong, Yeelana Shen, Michael Culler, the International Peptide Symposium . 2001

机译：人甲状旁腺激素和人甲状旁腺激素相关蛋白的高效类似物
5. Effects of parathyroid hormone analogues on hematopoietic stem cell niche potential of bone-marrow mononuclear cells. [D] . Umetsu, Akiko. 2009

机译：甲状旁腺激素类似物对骨髓单个核细胞造血干细胞小生境潜力的影响。
6. Engineering of Therapeutic Polypeptides Through Chemical Synthesis: Early Lessons From Human Parathyroid Hormone and Analogs [O] . Suwei Dong, Shiying Shang, Jianfeng Li, -1

机译：治疗性多肽工程通过化学合成：早期的经验教训从人甲状旁腺激素类似物和
7. Engineering of Therapeutic Polypeptides through Chemical Synthesis: Early Lessons from Human Parathyroid Hormone and Analogues [O] . Suwei Dong, Shiying Shang, Jianfeng Li, 2012

机译：通过化学合成治疗多肽的工程：来自人甲状旁腺激素和类似物的早期课程
8. Polypeptide Derivatives of Parathyroid Hormone (PTH). [R] . Gardella, T. J., Kronenberg, H. M., Potts, J. T., 2005

机译：甲状旁腺激素（pTH）的多肽衍生物。

Engineering of Therapeutic Polypeptides through Chemical Synthesis: Early Lessons from Human Parathyroid Hormone and Analogues

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