Biologically Active Polymersomes from Amphiphilic Glycopeptides

摘要

Polypeptide block copolymers with different block length ratios were obtained by sequential ring-opening polymerization of benzyl-L-glutamate and prop-argylglycine (PG) N-carboxyanhydrides. Glycosylation of the poly(PG) block was obtained by Huisgens cyclo-addition "click" reaction using azide-functionalized gal-actose. All copolymers were self-assembled using the nanoprecipitation method to obtain spherical and worm-like micelles as well as polymersomes depending on the block length ratio and the nanoprecipitation conditions. These structures display bioactive galactose units in the polymersome shell, as proven by selective lectin binding experiments.