Biotin[6]uril Esters: Chloride-Selective Transmembrane Anion Carriers Employing C-H…Anion Interactions

摘要

Biotin[6]uril hexaesters represent a new class of anionophores which operate solely through C-H…anion interactions. The use of soft H-bond donors favors the transport of less hydrophilic anions (e.g., Cl~-, NO_3 ~-) over hard, stongly hydrated anions (e.g., HCO_3~-and SO_4~(2-)). Especially relevant is the selectivity between chloride and bicarbonate, the major inorganic anions in biological systems.