STRETCHING TOWARD SIMPLE RELATIVE CONFIGURATION DETERMINATION

摘要

Scientists create and screen vast libraries of natural and synthetic compounds in hopes of identifying a new miracle drug or other useful and valuable commodity. However, figuring out the relative stereochemical configuration of small organic molecules, a key characteristic that determines function, is challenging with current methods especially if the compound is only available in minute quantities. Now, researchers led by Armando Navarro-Vazquez, Christian Griesinger, and Yizhou Liu have developed a simple approach for determining relative configuration using an NMR parameter called the residual chemical shift anisotropy that requires only micrograms of sample (DOI: 10.1021/ jacs.6b04082).