Short hydrogen bonds in the catalytic mechanism of serine proteases

VLADIMIR LESKOVAC; SVETLANA TRIVIC; DRAGINJA PERICIN; MIRA POPOVIC; JULIJAN KANDRAC

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Short hydrogen bonds in the catalytic mechanism of serine proteases

机译：丝氨酸蛋白酶催化机制中的短氢键

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The survey of crystallographic data from the Protein Data Bank for 37 structures of trypsin and other serine proteases at a resolution of 0.78-1.28 A revealed the presence of hydrogen bonds in the active site of the enzymes, which are formed between the c

机译：来自蛋白质数据库的晶体学数据调查显示，胰蛋白酶和其他丝氨酸蛋白酶的37种结构的分辨率为0.78-1.28 A，表明在酶的活性位点中存在氢键，这些氢键形成在c

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来源
《Journal of the Serbian Chemical Society》 |2008年第4期|p.393-403|共11页
作者
VLADIMIR LESKOVAC; SVETLANA TRIVIC; DRAGINJA PERICIN; MIRA POPOVIC; JULIJAN KANDRAC;
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作者单位

Faculty of Technology, University of Novi Sad, Novi Sad, Serbia;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
trypsin; serine proteases; low-barrier hydrogen bonds;

机译：胰蛋白酶;丝氨酸蛋白酶;低势垒氢键;

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专利

1. Short hydrogen bonds in the catalytic mechanism of serine proteases [J] . Leskovac Vladimir, Trivi? Svetlana, Peri?in Draginja, Journal of the Serbian Chemical Society . 2008,第4期

机译：短氢键在丝氨酸蛋白酶的催化机理中
2. Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis [J] . Fuhrmann CN, Daugherty MD, Agard DA Journal of the American Chemical Society . 2006,第28期

机译：Subangstrom晶体学表明，短的离子氢键而不是His-Asp低势垒氢键可稳定丝氨酸蛋白酶催化的过渡态
3. Direct evidence of a low barrier hydrogen bond in the catalytic triad of a Serine protease [J] . Peter Agback, Tatiana Agback Scientific reports. . 2018,第1期

机译：丝氨酸蛋白酶催化三联体中低势垒氢键的直接证据
4. Specific cleavage of Lys-147/Gly-1448 in the serine protease domain of human factor IXabeta by plasmin:effect on catalytic efficiency and factor VIIIa binding [C] . Amy E.Schmidt, S.Paul Bajaj the International Peptide Symposium . 2001

机译：通过纤溶酶在人体因子Ixabeta的丝氨酸蛋白酶结构域中的Lys-147 / gly-1448的特异性切割：对催化效率和因子viiia结合的影响
5. A computational characterization of hydrogen bonding in serine proteases. [D] . Molina Pico, Pablo Alberto. 2003

机译：丝氨酸蛋白酶中氢键的计算特征。
6. Direct evidence of a low barrier hydrogen bond in the catalytic triad of a Serine protease [O] . Peter Agback, Tatiana Agback -1

机译：丝氨酸蛋白酶催化三联体中低势垒氢键的直接证据
7. Nuclear magnetic resonance studies of the catalytic mechanism of proteolytic enzymes. Ionization behavior of the histidine residue in the catalytic triad of alpha-lytic protease--implications for the catalytic mechanism of serine proteases. Ionization behavior of enzymic and inhibitor groups in the tetrahedral adduct between alpha-lytic protease and a peptide aldehyde. Kinetics of pepsin-catalyzed hydrolysis of N-tri-fluoroacetyl amino acids [O] . Hunkapiller Michael W. 1974

机译：核磁共振研究蛋白水解酶的催化机制。组氨酸残基在α-裂解蛋白酶催化三联体中的电离行为 - 对丝氨酸蛋白酶催化机制的影响。在α-裂解蛋白酶和肽醛之间的四面体加合物中酶和抑制剂基团的电离行为。胃蛋白酶催化水解N-三氟乙酰氨基酸的动力学

Short hydrogen bonds in the catalytic mechanism of serine proteases

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