Eco-friendly Pest Management Using Monoterpenoids. I. Antifungal Efficacy of Thymol Derivatives

摘要

Ether and ester derivatives of thymol, 5-methyl-2-(1-methyl ethyl) phenol, a natural monoterpenoid, were synthesized and antifungal potency against Aspergillus niger, Aspergillus oryzae, Fusarium oxysporum and Alternaria alternata was evaluated to study structure-activity relationships. Thymyl ethers showed better antifungal potency than esters in overall studies. The data suggested that in eight simple ethers and three esters, the addition of a methylene group or a carbon, an olefinic bond or an aromatic moiety in side chain led to compounds with improved potency over the parent compound, thymol.