Development, characterization and investigation of anti-inflammatory potential of valdecoxib topical gels

摘要

This study presents formulation of topically effective controlled release valdecoxib gels and evaluates potential of gels as carriers for delivery of valdecoxib. In vitro drug release pattern for all formulations were found to be zero order diffusion controlled release. All formulations were compatible with skin and stable as per ICH guidelines. Optimized valdecoxib gel significantly reduced paw oedema up to 79.51% after 6 h, whereas it was found nonsignificant to inhibit 5-lipoxygenase even though with more doses. Valdecoxib gel with 0.5 g Carbopol is found optimized formulation to treat local inflammation.