Concurrent whole brain radiotherapy and short-course chloroquine in patients with brain metastases: a pilot trial

Harriet B. Eldredge; Albert DeNittis; James B. DuHadaway; Michael Chernick; Richard Metz; George C. Prendergast

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Concurrent whole brain radiotherapy and short-course chloroquine in patients with brain metastases: a pilot trial

机译：脑转移患者同时全脑放疗和短程氯喹：一项试验性试验

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摘要

Objective The immune modulatory drug chloroquine (CQ) has been demonstrated to enhance survival following radiotherapy in patients with high-grade glioma in a clinical trial, but the efficacy in patients with brain metastases is unknown. We hypothesized that short-course CQ during whole brain radiotherapy (WBRT) would improve response to local therapy in patients with brain metastases.

机译：目的在临床试验中已证明免疫调节药物氯喹（CQ）可以提高放疗后高级别神经胶质瘤患者的生存率，但对脑转移患者的疗效尚不清楚。我们假设全脑放疗（WBRT）期间的短程CQ可改善脑转移患者对局部治疗的反应。

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来源
《Journal of Radiation Oncology》 |2013年第3期|315-321|共7页
作者
Harriet B. Eldredge; Albert DeNittis; James B. DuHadaway; Michael Chernick; Richard Metz; George C. Prendergast;
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作者单位

Department of Radiation Oncology Lankenau Medical Center">(1);

Kimmel Cancer Center Thomas Jefferson University">(4);

Department of Radiation Oncology Lankenau Medical Center">(1);

Lankenau Institute for Medical Research">(2);

Lankenau Institute for Medical Research">(2);

Lankenau Institute for Medical Research">(2);

New Link Genetics Corporation">(3);

Lankenau Institute for Medical Research">(2);

Kimmel Cancer Center Thomas Jefferson University">(4);

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原文格式 PDF
正文语种 eng
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关键词
Brain metastases; Chloroquine; Immunotherapy; Immunomodulation; Indoleamine 2,3-dioxygenase (Ido); Non-small cell lung cancer (Nsclc); Whole brain radiotherapy;

机译：脑转移;氯喹;免疫疗法免疫调节吲哚胺2,3-二加氧酶（Ido）;非小细胞肺癌（Nsclc）;全脑放疗;

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专利

1. Concurrent whole brain radiotherapy and short-course chloroquine in patients with brain metastases: a pilot trial [J] . Harriet B. Eldredge, Albert DeNittis, James B. DuHadaway, Journal of radiation oncology . 2013,第3期

机译：脑转移患者同时全脑放疗和短疗程氯喹：一项先导试验
2. Concurrent whole brain radiotherapy and short-course chloroquine in patients with brain metastases: a pilot trial [J] . Harriet B. Eldredge, Albert DeNittis, James B. DuHadaway, Journal of radiation oncology . 2013,第3期

机译：脑转移患者同时全脑放疗和短疗程氯喹：一项先导试验
3. Pemetrexed and cisplatin combination with concurrent whole brain radiotherapy in patients with brain metastases of lung adenocarcinoma: a single-arm phase II clinical trial. [J] . Xiao-Xiao Dinglin, Yan Huang, Hui Liu, Journal of neuro-oncology. . 2013,第3期

机译：培美曲塞和顺铂联合并发全脑放疗治疗肺腺癌脑转移患者：单臂II期临床试验。
4. Identification of Rules for Brain Metastases and Survival Time Prediction for Small Cell Lung Cancer Patients [C] . Kwei Aryeetey, Wojciech Ziarko, Patricia Tai, International Symposium on "Intelligent Information Systems X", Jun 18-22, 2001, Zakopane, Poland . 2001

机译：小细胞肺癌患者脑转移和生存时间预测规则的确定
5. Results of a randomized, controlled trial to assess the toxicity and patient adherence with two short-course regimens for the prevention of tuberculosis, a two-month regimen of rifampin and pyrazinamide or a four-month regimen of rifampin only, in comparison with a control regimen of six-months-isoniazid. [D] . Geiter, Lawrence James. 1997

机译：与对照相比，采用两种短期疗程预防结核病，两个月利福平和吡嗪酰胺治疗或仅四个月利福平治疗，评估毒性和患者依从性的随机对照试验结果六个月异烟肼的治疗方案。
6. CONCURRENT WHOLE BRAIN RADIOTHERAPY AND SHORT-COURSE CHLOROQUINE IN PATIENTS WITH BRAIN METASTASES: A PILOT TRIAL [O] . Harriet Belding Eldredge, Albert DeNittis, James B. DuHadaway, -1

机译：患有脑转移的患者同时进行全脑放疗和短程氯喹：先导试验
7. Brain Radiotherapy plus Concurrent Temozolomide versus Radiotherapy Alone for Patients with Brain Metastases: A Meta-Analysis. [O] . Qian Zhao, Qin Qin, Jinglong Sun, 2016

机译：脑放射疗法加竞争剂替莫唑胺与脑转移患者单独放疗：meta分析。

Concurrent whole brain radiotherapy and short-course chloroquine in patients with brain metastases: a pilot trial

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