Effect of locally administered zoledronic acid on injury-induced intramembranous bone regeneration and osseointegration of a titanium implant in rats

Simo S. A. Miettinen; Jarkko Jaatinen; Alpo Pelttari; Reijo Lappalainen; Jukka M?nkk?nen; Petri K. Venesmaa; Heikki P. J. Kr?ger

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Effect of locally administered zoledronic acid on injury-induced intramembranous bone regeneration and osseointegration of a titanium implant in rats

机译：唑来膦酸局部给药对大鼠钛诱导的损伤膜内骨再生和骨整合的影响

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Intramedullary implantation causes injury-induced stimulation of intramembranous bone regeneration. Intramedullary bone injury along with stress shielding may induce periimplant bone loss and cause early aseptic loosening of an implant. The aim of this study was to determine the effect of locally administered zoledronic acid on periimplant bone and injury-induced stimulation of intramembranous bone regeneration in a rat model.

机译：髓内植入引起损伤引起的膜内骨再生的刺激。髓内骨损伤以及应力屏蔽可能会导致植入物周围骨质流失并导致植入物的早期无菌性松动。这项研究的目的是确定在大鼠模型中局部施用唑来膦酸对植入物周围骨的影响以及损伤诱导的膜内骨再生的刺激。

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《Journal of Orthopaedic Science》 |2009年第4期|431-436|共6页
作者
Simo S. A. Miettinen; Jarkko Jaatinen; Alpo Pelttari; Reijo Lappalainen; Jukka M?nkk?nen; Petri K. Venesmaa; Heikki P. J. Kr?ger;
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Bone and Cartilage Research Unit Faculty of Medicine Institute of Clinical Medicine University of Kuopio P.O. Box 1777 70211 Kuopio Finland;

Bone and Cartilage Research Unit Faculty of Medicine Institute of Clinical Medicine University of Kuopio P.O. Box 1777 70211 Kuopio Finland;

Laboratory of Electron Microscopy University of Kuopio Kuopio Finland;

BioMater Center Department of Physics University of Kuopio Kuopio Finland;

Department of Pharmaceutics University of Kuopio Kuopio Finland;

Department of Orthopaedics and Traumatology Kuopio University Hospital Kuopio Finland;

Bone and Cartilage Research Unit Faculty of Medicine Institute of Clinical Medicine University of Kuopio P.O. Box 1777 70211 Kuopio Finland;

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1. Effect of locally administered zoledronic acid on injury-induced intramembranous bone regeneration and osseointegration of a titanium implant in rats. [J] . Miettinen SS, Jaatinen J, Pelttari A, Journal of orthopaedic science : . 2009,第4期

机译：唑来膦酸局部给药对大鼠钛诱导的损伤诱导的膜内骨再生和骨整合的影响。
2. Effect of systemic administered zoledronic acid on osseointegration of a titanium implant in ovariectomized rats [J] . DikicierE., Kara?ayliü., DikicierS., Journal of Cranio-Maxillofacial Surgery . 2014,第7期

机译：全身施用唑来膦酸对去卵巢大鼠体内钛植入物骨整合的影响
3. Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study [J] . Nam-Ho Kim, So-Hyoun Lee, Jae-Jun Ryu, BioMed research international . 2015,第40期

机译：RHBMP-2对耐酸和酸蚀刻钛植入表面对骨再生和骨整合的影响：溢出口设计试验研究
4. Enhancing osseointegration by site-specific laser modification of titanium implants: comparative and correlative analyses of different parameters of bone-implant integration [C] . Omar Omar, Martin L Johansson, Furqan A Shah, World biomaterials congress . 2016

机译：通过特定位置的钛植入物激光修饰增强骨整合：不同参数的骨植入物整合的比较和相关分析
5. Osseointegration of dental implants in early regenerate bone produced by bone transport distraction osteogenesis. [D] . Kontogiorgos, Elias Dimitrios. 2010

机译：牙齿植入物在骨再生中的早期整合是通过骨运输分散性成骨产生的。
6. Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study [O] . Nam-Ho Kim, So-Hyoun Lee, Jae-Jun Ryu, -1

机译：rhBMP-2对喷砂和酸蚀钛植入物表面骨再生和骨整合的影响：尖嘴设计的先导研究
7. Effects of Gamma Radiation-Induced Crosslinking of Collagen Type I Coated Dental Titanium Implants on Osseointegration and Bone Regeneration [O] . Won-Tak Cho, So-Yeun Kim, Sung-In Jung, 2021

机译：胶原型I涂层牙型钛植入物对骨整合和骨再生的影响γ辐射诱导交联的影响

Effect of locally administered zoledronic acid on injury-induced intramembranous bone regeneration and osseointegration of a titanium implant in rats

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