An unexpected rate acceleration-practical improvements in the baylis-hillman reaction

摘要

The formation of carbon-carbon bonds in a controlled manner lies at the core of organic synthesis. Generally, these reactions require the preformation of a carbanionic or organometallic species followed by the addition of a carbon electrophile. One notable exception to this axiom is the Baylis-Hillman reaction, which entails a tertiary amine-catalyzed coupling of an acrylate and an aldehyde (eq 1).