1-aryl-2-pyridyl-3,4-dihydronaphthalenes: photofluorogenic ligands for the estrogen receptor

摘要

Three 1,2-substituted-3,4-dihydronaphthalenes that are pyridine analogs of the antiestrogen desmethylnafoxidine were prepared and evaluated as fluorescent ligands for the estrogen receptor. These compounds represent a class of fluorescent probes that we term "photofuorogenic", denoting Their ability to exist initially as a high affinity though weakly fluorescent stilbazole form which Can be photocyclized-oxidized to a highly fluorescent though low affinity azaphenanthrenoid form.