An Asymmetric Route to Chiral, Nonracemic 2-Substituted Piperidines. Synthesis of (-)-Pipecoline, (+)-Coniine, and (-)-Coniceine

摘要

A simple procedure has been devised for the preparation of chiral, nonracemic 2-substituted pip-eridines in high enantiomeric purity. Additionally, a route to bicyclic lactams containing a range of angular substitutions has been achieved which further enhances the synthetic utility of chiral bicyclic lactams.