Enantioselective Recognition by a New Chiral Stationary Phase at Receptorial Level

摘要

A wide variety of chiral stationary phases (CSPs) for HPLG applications have been so far developed, enabling enantiomer separations of a broad range of compounds with different types and combination of functionalities and stereogenic elements.Proteins, carbohydrates, synthetic polymers, cyclodextrins, macrocyclic antibiotics, and low molecular weight synthetic selectors have been linked to or adsorbed on solid supports yielding effective sorbents for analytical and/or preparative separations.Small, synthetically accessible selectors offer some distinct advantages over high molecular weight biopolymers as they are amenable to extensive chemical manipulations allowing a rational optimization of both structure and grafting mode; moreover, soluble models mimicking the CSP modes of action can be used to spectroscopically elucidate the recognition process.