A Modular and Concise Total Synthesis of (+-)-Daurichromenic Acid and Analogues

摘要

A modular and concise total synthesis of (+-)-daurichromenic acid has been accomplished in four steps from ethyl acetoacetate, ethyl crotonate, and trans, trans-farnesal. A series of analogues of this natural product, which has potent anti-HIV activity, were also prepared from ethyl or methyl acetoacetate and a series of readily available α,β-unsaturated esters and aldehydes.