Synthesis of Cyclic β-Amino Acid Esters from Methionine, Allylglycine, and Serine

摘要

Here we report a versatile ring-closing metathesis-based approach to 5-, 6-, and 7-membered cyclic β-amino esters starting with simple and readily available building blocks-methionine, allylglycine, and serine-where the nature of the amino acid determines the size of the carbocyclic ring.