Novel and Expeditious Microwave-Assisted Three-Component Reactions for the Synthesis of Spiroimidazolin-4-ones

摘要

Highly efficient methods for the syntheses of spiroimidazolinones via microwave-assisted three-component one-pot sequential reactions or one-pot domino reactions are described.The efficiency and utility of the methods have been demonstrated by quickly accessing the antihypertensive drug irbesartan(2).Microwave-assisted organic synthesis has impacted synthetic chemistry significantly since the introduction of precision-controlled microwave reactors.Numerous reactions including heterocycle-forming,metal catalyzed cross-coupling,condensation,and cycloaddition reactions have been explored under microwave conditions.In addition,microwave-heating technology has been applied in the total syntheses of natural products.