Directed Ortho Metallation of Deep Cavity Cavitands: Functionalizing Molecular Concavity

摘要

Directed ortho metallation (DOM) processes have been used to functionalize the cavity and rim of title cavitand 1.The preorganization of the host resulted in a considerable reduction in the range of products produced.Thus,whereas sixty-nine products are possible from per-functionalization,only twelve were observed when the host was treated with three different alkyllithiums.