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首页> 外文期刊>Journal of neural engineering >Chronic pudendal neuromodulation using an implantable microstimulator improves voiding function in diabetic rats
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Chronic pudendal neuromodulation using an implantable microstimulator improves voiding function in diabetic rats

机译：使用植入式微刺激器进行慢性阴部神经调节可改善糖尿病大鼠的排尿功能

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摘要

Objective. Few studies have investigated the feasibility of using chronic pudendal neuromodulation for improving voiding function in patients with diabetes who are also experiencing urinary retention. The present study investigated the effects of chronic electrical stimulation (ES) of the sensory branch of the pudendal nerve on voiding function in diabetic rats. Approach. A custom-made implantable microstimulation system was designed and manufactured for chronic implantation in normal control (NC) and diabetic rats. After three or six weeks of pudendal neuromodulation, the intravesical pressure, external urethral sphincter electromyograms (EUS-EMGs), and urine flow rate (UFR) of all rats were simultaneously recorded to assess the effects of chronic pudendal ES on voiding function. Morphological changes in pudendal axons were assessed through hematoxylin and eosin (H&E) staining. Results. Abnormal cystometric measurements, including an increased volume threshold, contraction amplitude, and residual volume (RV) as well as a decreased burst period (BP) indicated voiding dysfunction in the diabetic rats with sham ES for three or six weeks. However, real ES for three or six weeks reversed these abnormal results; these parameters became similar to those of the NC rats and, consequently, voiding efficiency (VE) increased significantly from 17%-45% to 51%-57%. The cross-sectional area and axonal density of the pudendal nerve decreased in all the diabetic rats with sham ES for six weeks; however, these values increased significantly after real ES for six weeks. Significance. This study demonstrated the feasibility of using chronic pudendal neuromodulation for improving voiding function in diabetic rats. These results may facilitate the development of an advanced neural prosthesis for restoring bladder function in clinical settings.
机译：目的。很少有研究调查使用慢性阴部神经调节改善患有尿留的糖尿病患者排尿功能的可行性。本研究调查了慢性神经电刺激的阴部神经感觉分支对糖尿病大鼠排尿功能的影响。方法。设计并制造了定制植入式微刺激系统，用于正常对照组（NC）和糖尿病大鼠的慢性植入。在进行3到6周的阴部神经调节后，同时记录所有大鼠的膀胱内压，尿道外括约肌肌电图（EUS-EMGs）和尿流率（UFR），以评估慢性阴部ES对排尿功能的影响。通过苏木精和曙红（H＆E）染色评估阴部轴突的形态学变化。结果。异常的膀胱测压测量，包括增加的容积阈值，收缩幅度和残余容积（RV）以及减少的猝发期（BP），表明在患有假ES的糖尿病大鼠中排尿功能障碍三到六周。但是，经过3到6周的真实ES可以扭转这些异常结果。这些参数变得与NC大鼠相似，因此，排尿效率（VE）从17％-45％显着提高到51％-57％。在所有假手术为期6周的糖尿病大鼠中，其阴部神经的横截面积和轴突密度均下降。但是，经过真正的ES六周后，这些值显着增加。意义。这项研究证明了使用慢性阴部神经调节改善糖尿病大鼠排尿功能的可行性。这些结果可能有助于开发先进的神经假体，以在临床环境中恢复膀胱功能。

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  • 来源
    《Journal of neural engineering》 |2016年第4期|046001.1-046001.12|共12页
  • 作者

    Tsung-Hsun Hsieh; Yin-Tsong Lin; Shih-Ching Chen; Chih-Wei Peng;

  • 作者单位

    Graduate Institute of Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan,Department of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine and Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan,Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan;

    School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan,Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan;

    Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan,Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan;

    School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan,Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan,Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan,Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan;

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  • 正文语种 eng
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  • 关键词

    neuromodulation; electrical stimulation; voiding; intravesical pressure;

    机译：神经调节电刺激排尿膀胱内压;

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