Recombinant vaccinia virus is an effective and non-perturbing vector for human dendritic cells transfected with epstein-barr virus latent membrane protein 2A

摘要

Conclu- sion Recombinant vaccinia virus was an effective and non-perturbing vector to mediate the transfec- tion of LMP2A into DC. the functions of mature DC were not affected significantly by the transfec- tion of Vac-LMP2A. This study could provide evidence for the further immunotherapy of EBV-asso- ciated malignancies, e.g. nasopharyngeal carcinoma(NPC). Objective To study the effects of dendritic cells9DC)transfected with recom- Binant vaccinia virus encoding Epstein-Barr virus(EBV)latent membrane protein 2A(LMP2A) Gene, and to provide evidence for further investigation on the therapeutic vaccines against EBV-as- Sociated malignancies.