Diagnosis and management of late hepatic allograft dysfunction

摘要

Late hepatic allograft dysfunction (LHAD) is common after liver transplantation (LT) and can cause graft failure ,retransplantation, or even death. A variety of etiologies including rejection, vascular complications, bile duct complications, recurrent diseases, infections, de novo diseases, neoplasms and drug toxicity can result in LHAD. The recurrent diseases have the potential to become the most serious problems facing LT in the future. It is difficult to differentiate late acute rejection from recurrent viral or autoimmune hepatitis. Accurate diagnosis of the cause of LHAD has therapeutic importance.