Steady-state analysis of a continuum model for super-infection

摘要

A large system of N strains of parasite and a single host is analyzed as a function of the degree of virulence in the strains when there is super-infection between hosts (more virulent strains can infect hosts that are already infected) and within-host transition between strains that is neutral. When this small amount of local switching is allowed, steady-state solutions converge to a continuous distribution as the number of strains increases. The resulting nonlinear-nonautonomous integro-differential equation is reduced to a fourth order boundary value problem (BVP) and the existence of positive solutions is proven. The methods here and associated BVP allow for a thorough exploration of parameter space for this class of models.