Synthesis, bioactivity and preliminary biocompatibility studies of glasses in the system CaO-MgO-SiO_2-Na_2O-P_2O5-CaF_2

摘要

New compositions of bioactive glasses are proposed in the CaO-MgO-SiO_2-Na_2O-P_2O_5-CaF_2 system. Mineralization tests with immersion of the investigated glasses in simulated body fluid (SBF) at 37°C showed that the glasses favour the surface formation of hydroxyapatite (HA) from the early stages of the experiments. In the case of daily renewable SBF, monetite (CaHPO_4) formation competed with the formation of HA. The influence of structural features of the glasses on their mineralization (bioactivity) performance is discussed. Preliminary in vitro experiments with osteoblasts' cell-cultures showed that the glasses are biocompatible and there is no evidence of toxicity. Sintering and devitrification studies of glass powder compacts were also performed. Glass-ceramics with attractive properties were obtained after heat treatment of the glasses at relatively low temperatures (up to 850°C).