Synthesis, structure, bioactivity and biocompatibility of melt-derived P2O5-CaO-B2O3-K2O-MoO3 glasses

摘要

New glasses following the P2O5-CaO-B2O3-K2O-MoO3 composition were prepared using the classical melt quenching method in order to investigate and correlate their structural peculiarities with the composition and, moreover, with the bioactivity and biocompatibility behavior. The structure and surface morphology of samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Two complementary techniques were used to determine the elemental composition inside samples and on the outermost layer of their surface, namely energy dispersive X-ray (EDX) and X-ray photoelectron spectroscopy (XPS), respectively. For assessing in vitro the bioactivity of the synthesized glasses, the ability to form hydroxyapatite crystallites on their surface upon immersion in simulated body fluid (SBF) was checked using SEM and EDX analysis. The in vitro cytotoxic effect of samples was evaluated using a mitochondria) activity assay.