Antibacterial and anticancerous drug loading kinetics for (10-x) CuO-xZnO-20CaO-60SiO(2)-10P(2)O(5) (2 <= x <= 8) mesoporous bioactive glasses

摘要

In the present study, antibacterial and anticancerous drug loading kinetics for the (10-x) CuO-xZnO-20CaO-60SiO(2)-10P(2)O(5) (2 <= x <= 8, varying in steps of 2) mesoporous bioactive glasses (MBGs) have been studied. XRD analysis of the as prepared glass samples proved its amorphous nature. Scanning electron microscopy (SEM) revealed the apatite layer formation on the surface of the MBGs after soaking for 15 days in SBF. Ion dissolution studies of calcium, phosphorous and silicon have been performed using inductively coupled plasma (ICP). FTIR and Raman analysis depicted about the presence of various bonds and groups present in the glasses. The pore size of MBGs lies in the range of 4.2-9.7 nm. Apart from this, specific surface area of the MBGs varied from 263 to 402 cm(2)/g. The MBGs were loaded with Doxorubicin (DOX), Vancomycin (VANCO) and Tetracycline (TETRA) drugs among which, the decreasing copper content influenced the loading properties of doxorubicin and tetracycline drugs. Vancomycin was fully loaded almost in all the MBGs, whereas other drugs depicted varying loading with respect to the copper content.