Synthesis, Structural Characterization, And Initial Evaluation As Anticancer Drugs Of Dibutyltin Polyamines Derived From Various 4,6-diaminopyrimidines

摘要

A number of diaminopyrimidines have been incorporated into dibutyltin polyamines with molecular weights ranging from 3.5 × 10~4 to 3.7 × 10~6 and product yields from 47 to 88%. Infrared spectroscopy is consistent with the inclusion of the diaminopyridines into the polymer backbone with the IR spectroscopy showing the formation of the Sn-N bond as well as the presence of bands from both reactants being present in the polymer. F MALDI MS is also consistent with the products being polymeric and containing units from both the dibutyltin and pyrimidine reactants. The products exhibit good inhibition of cancer cell lines including those derived from human lung, bone, breast, prostrate, and colon cancers. Inhibition occurs within the same concentration range, and lower than that of the most widely employed chemotherapeutic drug, cis-platin.