Synthesis, Structural Analysis, Fiber Formation and Preliminary Anticancer Characterization of the Organotin Polyether from Dibutyltin Dichloride and 2,5-Dimethyl-3-hexyne-2,5-diol

摘要

The organotin polyether derived from reaction of dibutyltin dichloride and 2,5-dimethyl-3-hexyne-2,5-diol was rapidly synthesized employing classical interfacial polymerization in 65% yield and a chain length of 360 units. IR results are consistent with the polyether structure. Bands characteristic of the formation of the Sn-0 are present and bands characteristic of the Sn-CI are absent. F MALDI MS results in the low mass range gives ion fragment clusters to five units. Isotopic abundance matches for tin are consistent with its presence in these ion fragment clusters. In the high mass range ion fragment clusterito greater than 300 units are found. The products offer outstanding inhibition of a wide range of cancer cell lines showing inhibition of prostate, breast, and colon human cancer cell lines. The product spontaneously forms fibers. Mdssbauer results are consistent with the fibers existing in a very constrained molecular environment and being present in about 50% of the product consistent with that visually observed.