Drug Release Behavior and Antitumor Efficiency of 5-ASA Loaded Chitosan-Layered Silicate Nanocomposites

摘要

5-Amino salicylic acid (5-ASA) loaded chitosan (CS)-montmorillonite nanocomposites were prepared by different methods and using different ratios of modified CS. CS was modified first through chloroacetylation followed by formation of phosphonium salt. The intercalation occurred through ion exchange process between sodium cations in MMT and phosphonium ions in the modified CS. The structure of the resulting composites as determined by Infra red spectroscopy, X-ray diffraction, consisted of the insertions of modified CS between lamellar layers. The modified CS is strongly fixed to layered silicate. The morphology of these materials was examined by transmission electron microscopy. The thermal stability of the nanocomposite was investigated by thermogravimetry analysis. The release of 5-ASA behavior from nanocomposites at different pH (5.4 and 7.8) was assessed. The dispersed layered silicate platelets encase the 5-ASA retarding the release of the drug molecule in the nanocomposite. Furthermore, their use as antitumor agents for treatment of colon cancer is investigated.