• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Food Science >Anti-obesity effect of Liupao tea extract by modulating lipid metabolism and oxidative stress in high-fat-diet-induced obese mice
【24h】

Anti-obesity effect of Liupao tea extract by modulating lipid metabolism and oxidative stress in high-fat-diet-induced obese mice

机译：通过调节高脂饮食诱导的肥胖小鼠脂质代谢和氧化应激六芍茶提取物的抗肥胖作用

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Liupao tea (LPT) is traditional dark Chinese tea. The effect of LPT extract on high-fat-diet-induced obese mice was investigated systematically. The results showed that LPT extract could reduce body weight and significantly alleviate liver damage and fat accumulation. LPT could also decrease the levels of alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (AKP), total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) and increase the level of high-density lipoprotein cholesterol (HDL-C) in the liver. It also decreased the serum levels of inflammatory cytokines, including tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interleukin (IL)-1β, and IL-6 and increased the serum levels of anti-inflammatory cytokines, including IL-10 and IL-4. Moreover, LPT improved the levels of total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) and reduced the level of malondialdehyde (MDA) in the liver. Moreover, LPT could upregulate the raRNA and protein expressions of peroxisome proliferator-activated receptor alpha (PPAR-α), lipoprotein lipase (LPL), carnitine palmitoyltransferase 1(CPT1), and cholesterol 7 alpha-hydroxylase (CYP7A1) and downregulate those of PPAR-γ and CCAAT/enhancer-binding protein alpha (C/EBP-α) in the liver. It also increased the mRNA expression of copper/zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), CAT, gamma-glutamylcysteine synthetase 1 (GSH1), and GSH-Px. The components of LPT extract include catechin, rutin, taxifolin, and astragalin, which possibly have a wide range of biological activities. In conclusion, our work verified that LPT extract possessed an anti-obesity effect and alleviated obesity-related symptoms, including lipid metabolism disorder, chronic low-grade inflammation, and liver damage, by modulating lipid metabolism and oxidative stress.
机译：六浩茶（LPT）是传统的深色中国茶。系统地研究了LPT提取物对高脂饮食诱导的肥胖小鼠的影响。结果表明，LPT提取物可以减轻体重并显着减轻肝损伤和脂肪积累。 LPT还可以降低丙氨酸氨基转移酶（ALT），天冬氨酸转氨酶（AST），碱性磷酸酶（AKP），总胆固醇（TC），甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）的水平并增加肝脏中高密度脂蛋白胆固醇（HDL-C）的水平。它还降低了血清炎性细胞因子的血清水平，包括肿瘤坏死因子α（TNF-α），干扰素γ（IFN-γ），白细胞介素（IL）-1β和IL-6并增加血清抗炎细胞因子水平，包括IL-10和IL-4。此外，LPT改善了超氧化物歧化酶（T-SOD），谷胱甘肽过氧化物酶（GSH-PX）和过氧化氢酶（猫）的水平，并降低了肝脏中丙二醛（MDA）的水平。此外，LPT可以上调过氧化物体增殖物激活的受体α（PPAR-α），脂蛋白脂肪酶（LPL），肉氨基棕榈酰转移酶1（CPT1）和胆固醇7α-羟化酶（CYP7A1）的RARNA和蛋白表达，并下调PPAR的那些肝脏中-γ和CCAAT /增强剂结合蛋白α（C / EBP-α）。它还增加了铜/锌超氧化物歧化酶（SOD1），锰超氧化物歧化酶（SOD2），猫，γ-谷氨酸氨基琥珀酰基合成酶1（GSH1）和GSH-PX的mRNA表达。 LPT提取物的组分包括儿茶素，Rutin，Taxifolin和黄芪，其可能具有各种各样的生物活性。总之，我们的工作证实，LPT提取物具有抗肥胖效应和缓解肥胖相关的症状，包括通过调节脂质代谢和氧化应激，包括脂质代谢障碍，慢性低级炎症和肝损伤。

著录项

  • 来源
    《Journal of Food Science》 |2021年第3期|215-227|共13页
  • 作者

    Ya Wu; Hailan Sun; Ruokun Yi; Fang Tan; Xin Zhao;

  • 作者单位

    Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing 400067 China Chongqing Engineering Research Center of Functional Food Chongqing University of Education Chongqing 400067 China Chongqing Engineering Laboratory for Research and Development of Functional Food Chongqing University of Education Chongqing 400067 China College of Biological and Chemical Engineering Chongqing University of Education Chongqing 400067 China;

    Department of Nutrition Chongqing Health Center for Women and Children Chongqing 400021 China;

    Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing 400067 China Chongqing Engineering Research Center of Functional Food Chongqing University of Education Chongqing 400067 China Chongqing Engineering Laboratory for Research and Development of Functional Food Chongqing University of Education Chongqing 400067 China;

    Department of Public Health Our Lady of Fatima University Valenzuela 838 Philippines;

    Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing 400067 China Chongqing Engineering Research Center of Functional Food Chongqing University of Education Chongqing 400067 China Chongqing Engineering Laboratory for Research and Development of Functional Food Chongqing University of Education Chongqing 400067 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    anti-inflammation; anti-obesity; antioxidant; high-fat diet; lipid metabolism; Liupao tea;

    机译：抗炎;反肥胖;抗氧化剂;高脂饮食;脂质代谢;六豪茶;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号