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Technical note: Adjustment of traditional cow evaluations to improve accuracy of genomic predictions

机译:技术说明:调整传统奶牛评估以提高基因组预测的准确性

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摘要

Genomic evaluations are calculated using deregressed predicted transmitting abilities (PTA) from traditional evaluations to estimate effects of single nucleotide polymorphisms. The direct genomic value (sum of an animal's marker effects) should be consistent with traditional PTA, which is the case for bulls. However, traditional PTA of yield traits (milk, fat, and protein) for genotyped cows are higher than their direct genomic values. To ensure that characteristics of cow PTA for yield traits were more similar to those for bull PTA, mean and variance of cow Mendelian sampling (PTA minus parent average) were adjusted to be similar to those of bulls. The same adjustments were used for all genotyped cows in a breed. To determine gains in reliabilities, predictions were made for bulls with August 2010 evaluations that did not have traditional evaluations in August 2006. By adjusting cow PTA and parent averages of genotyped animals, Holstein and Jersey regressions of August 2010 deregressed PTA on genomic evaluations based on August 2006 data became closer to 1 for the adjusted predictor population compared with the unadjusted predictor population. Evaluation bias was decreased for Holsteins when the predictor population was adjusted. Mean gain in reliability over parent average increased 3.5 percentage points across yield traits for Holsteins and 0.9 percentage points for Jerseys when the predictor population was adjusted. The accuracy of genomic evaluations for Holsteins and Jerseys was increased through better use of information from cows.
机译:基因组评估是使用传统评估中递减的预测传输能力(PTA)计算得出的,以评估单核苷酸多态性的影响。直接基因组值(动物标志物效应的总和)应与传统的PTA一致,公牛就是这种情况。然而,基因型母牛的传统产量特征(牛奶,脂肪和蛋白质)的PTA高于其直接基因组值。为确保奶牛PTA的产量性状特征与公牛PTA的特征更相似,将牛孟德尔抽样的均值和方差(PTA减去父本平均值)调整为与公牛的相似。对一个品种中的所有基因型奶牛都进行了相同的调整。为了确定可靠性的提高,对2010年8月评估的牛进行了预测,而2006年8月没有进行传统评估。通过调整牛PTA和基因型动物的父母平均值,2010年8月的Holstein和Jersey回归对基于基因组评估的PTA进行了回归分析。与未调整的预测变量相比,2006年8月调整后的预测变量的数据接近于1。调整预测变量后,荷斯坦的评估偏见降低。调整预测变量后,相对于父本的平均可靠性,荷斯坦奶牛的性状提高了3.5个百分点,泽西岛的性状提高了0.9个百分点。通过更好地利用来自奶牛的信息,可以提高对荷斯坦和泽西岛的基因组评估的准确性。

著录项

  • 来源
    《Journal of dairy science》 |2011年第12期|p.6188-6193|共6页
  • 作者单位

    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705-2350;

    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705-2350;

    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705-2350;

    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705-2350;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    genetic evaluation; genomic prediction; evaluation accuracy; bias;

    机译:基因评估;基因组预测评估准确性;偏压;
  • 入库时间 2022-08-17 23:24:41

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