Syntheses, characterizations, crystal structures, and in vitro antitumor activities of chiral triorganotin(IV) complexes containing (S)-(+)-2-(4-isobutyl-phenyl)propionic and (R)-(+)-2-(4-hydroxyphenoxy)propionic acid ligands

摘要

Four new chiral triorganotin(IV) carboxylates, [(R₃Sn)(O₂C₁₃H₁₇)] _n (R = Me 1, Ph 2), [(R₃Sn)(O₂C₁₃H₁₇)] (R = n-Bu 3), and [(R₃Sn)(O₄C₉H₉)] _n (R = Me 4), have been synthesized by reaction of (S)-(+)-2-(4-isobutyl-phenyl)propionic acid and (R)-(+)-2-(4hydroxyphenoxy)propionic acid with triorganotin(IV) chloride in the presence of sodium ethoxide. The complexes have been characterized by elemental analyses, FT-IR, NMR (1H, 13C, and 119Sn) spectra, and X-ray crystallography diffraction analyses. Structural analyses show that 1 has a 1-D infinite chiral zigzag chain structure. Complexes 2 and 4 have a 1-D spring-like chiral helical chain with a channel, while 3 is a monomer. Antitumor activities of 1-4 have been studied.View full textDownload full textKeywordsTriorganotin(IV) complexes, Chiral, (S)-(+)-2-(4-Isobutyl-phenyl)propionic acid, (R)-(+)-2-(4-Hydroxyphenoxy)propionic acid, Anticancer activityRelated var addthis_config = { ui_cobrand: "Taylor & Francis Online", services_compact: "citeulike,netvibes,twitter,technorati,delicious,linkedin,facebook,stumbleupon,digg,google,more", pubid: "ra-4dff56cd6bb1830b" }; Add to shortlist Link Permalink http://dx.doi.org/10.1080/00958972.2012.734814