Synthesis, crystal structures, and urease inhibition studies of two new Schiff-base copper complexes derived from n-butylamine

摘要

Two Schiff-base copper(II) complexes, bis(N-n-butyl-5-chlorosalicylaldiminato) copper(II) (1) and bis(N-n-butyl-4-methoxysalicylaldiminato) copper(II) (2), were synthesized and their solid-state structures were determined by X-ray crystallography. Complex 1 displays a distorted square-planar geometry, while 2 possesses square-planar geometry. Copper(II) complexes 1 and 2 showed strong inhibitory activity against jack bean urease (IC₅₀ = 2.7, 3.5 µmol L−1), compared with acetohydroxamic acid (IC₅₀ = 63.00 µmol L−1). A molecular modeling study was carried out via the DOCK program to gain understanding of the potent inhibitory activity of these copper species against jack bean urease.View full textDownload full textKeywordsSchiff-base copper(II) complexes, Crystal structures, 5-Chlorosalicylaldehyde, 4-Methoxysalicylaldehyde, Urease inhibitorsRelated var addthis_config = { ui_cobrand: "Taylor & Francis Online", services_compact: "citeulike,netvibes,twitter,technorati,delicious,linkedin,facebook,stumbleupon,digg,google,more", pubid: "ra-4dff56cd6bb1830b" }; Add to shortlist Link Permalink http://dx.doi.org/10.1080/00958972.2011.637169