Lack of mucin MUC5AC field change expression associated with tubulovillous and villous colorectal ademomas

摘要

Bacground-MUC5AC is a secreted mucin aberrantly expressed by polypoid colorectal adenomas. It has been hypoth- esised that the "normal" surrounding colorectal mucosa expresses MUC5AC as a field change phenomenon that can be used to predict adenoma recurrence fol- lowing resection. Aim-to determine if there is a field Change of de novo MUC5AC expression in Histologically normal rectal mucosa adja- Cent to villous and tubulovillous adeno- Mas, and thus whether MUC5AC Expression can be used as a marker of Early tumour recurrence.