Translating research into cancer molecular diagnostics and patents

摘要

In terms of the Diamond Jubilee celebration of the Journal of Clinical Pathology (JCP), it is evident that molecular pathology is still a relatively young field. Thus, one of the most notable papers published in the journal in this area appeared not 60 years ago, but only 15 years ago. In November 1990, in an article entitled "Mono-clonality in B cell lymphoma detected in paraffin wax embedded sections using the polymerase chain reaction", Alec Morley's group described the application of the polymerase chain reaction (PCR) to detect B cell morio-clonality in formalin fixed, paraffin wax embedded material. This was based on the use of consensus primers for the variable and joining regions of the IGH (immunoglobulin heavy chain) gene, as illustrated in figure 1 of that paper, which has been reproduced here (fig 1).