Multiple myeloma with bone marrow extracellular crystal deposition

摘要

Plasma cell dyscrasias are a heterogeneous group of disorders characterised by the expansion of a single clone of immunoglobulin secreting, terminally differentiated, end-stage B cells. Many of their clinical and morphological features are the result of the production and accumulation of excessive amounts of monoclonal immunoglobulin. Intracellular inclusions, both intracyto-plasmic (Russell bodies) and intranuclear (Dutcher bodies) are occasionally seen in bone marrow biopsy specimens from patients with plasma cell neoplasms, and less frequently in reactive states. Extracellular protein deposition also occurs, although less frequcntly.