MUC1 and MUC2 mucins in flat and polypoid colorecatal adenomas

摘要

Conclusions-MUC2/MUC1 phenotypes were similar in flat and polypoid adeno- mas when stratified by grade of atypia. High grade atypia was characterised by Reduced MUC2 and increased MUC1 Expression in both types of adenoma. The Phenotype MUC2-/MUC1 + occurs in tu- Bular adenomas and cannot be a specific Marker for de novo colorectal cancer. Aims-To examine the expression of MUC1 and MUC2 apomucins and distri- Bution of MUC phenotypes (MUC2 +/ MUC1-, MUC2+/MUC1+, MUC2-/ MUC1+, MUC2-/MUCL-) in colorectal Tubular adenomas in order to compare the Distribution of phenotypes in flat and Polypoid adenomas.