Co-localisation if insulin-like growth factor II and the proliferation marker MIB1 in hepatocellular carcinoma cells

摘要

Conclusions-Most of the Ki-67 antigen positive cells co-expressed IGF-II, sug- gesting that IGF-II may act as an auto- crine or paracrine growth factor, and may play an important role in the development of HCC. Aim-To assess the effect of insulin-like Growth factor II (IGF-II) on proliferation Of hepatocellular carcinoma (HCC) cells. Methods-Expression of IGF-II nRNA And protein was detected in 10 archival HCC specimens using in situ hybridisa- Tion and immunohistochemistry, respec- Tively. Expression of the Ki-67 antigen, a Proliferation marker, was determined im- Munohistochemically on the same sec- Tions.