Apolipoprotein E alleles in women with severe pre-eclampsia

摘要

This study investigated the frequency of apolipoprotein E (apoE) alleles among women with severe pre-eclampsia. The presence of the three most common apoE alleles (ε2,ε3,ε4) was determined by polymerase chain reaction-restriction fragment length polymorphism in three groups of white women: non-pregnant healthy (n=101), pregnant healthy (n=52), and pregnant with a diagnosis of severe pre-eclampsia (n=54). The fre- quency of apo ε2 was highest among women with severe pre-eclampsia (16.6 /100) followed by non-pregnant women (12.9/100), and those experiencing an healthy preg- nancy (10.6/100).