Severe hypoglycaemia caused by raised insulin-like growth factor II in disseminated breast cancer

摘要

A 60 year old woman with disseminated ductal carcinoma of the breast developed non-islet cell tumour induced hypoglycae- mia (NICTH). The concentrations of the two insulin -like growth factors, IGF-I and IGF-II, were <2 nmol/1 and 94.1 nmol/1, Respectively. The IGF-II to IGF-I ratio was >47 (normal <10). Insulin (<3 mu/1) and C peptide (< 100 pmol/1) were both under- Tectable.