Diagnostic and prognostic implications of the unfolding molecular biology of bone and soft tissue tumours

摘要

Sarcomas account for approximately 1- 2/100 of human malignant disease and are relatively uncommon. Histopathological study of these mesenchymal tumours at light microscopic and ultrastructural level may not always provide an unambiguous diagnosis. It has become apparent with the identification of increasing numbers of tumour specific genetic alterations that (cyto) genetic evaluation could become a very helpful adjunct to histopathological assessment in reaching a correct diagno- sis.